Fenofibrate is in a class of medications called antilipemic agents. It works by speeding the natural processes that remove cholesterol from the body.

What class of drug is fenofibrate?

Fenofibrate is in a class of medications called antilipemic agents. It works by speeding the natural processes that remove cholesterol from the body.

Can fenofibrate affect your blood pressure?

Fenofibrate, combined therapy, or candesartan all significantly reduced systolic and diastolic blood pressure after 2 months administration when compared with baseline.

Is TriCor a beta blocker?

Among the medications cardiologists are giving a second look: AbbVie’s Niaspan, or prescription niacin, which aims to raise good cholesterol; so-called fenofibrate such as top-selling branded drug TriCor (also from AbbVie), which lowers blood fats called triglycerides; and beta-blockers, most of which are inexpensive, …

What is the role of fenofibrate?

Fenofibrate is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It works by increasing the natural substance (enzyme) that breaks down fats in the blood.

What are the long term side effects of fenofibrate?

Fenofibrate can cause abnormal results in tests of liver function. These abnormal results can indicate liver damage. This drug can also cause other liver damage and inflammation after years of use.

How long can you take fenofibrate?

Monitoring of cholesterol/triglyceride levels every four to eight weeks is important to establish the effectiveness of fenofibrate therapy. Your doctor should consider discontinuing therapy if you have not had an adequate response after two months of treatment.

Can fenofibrate damage your liver?

Fenofibrate therapy is associated with mild and transient serum aminotransferase elevations and with rare instances of acute liver injury, which can be severe and prolonged and lead to significant hepatic fibrosis.

How safe is fenofibrate?

In general, fenofibrate can be considered a safe and well-tolerated lipid-lowering drug that has been scrutinized extensively for safety in clinical research and during an already long marketing period in Europe.

Is fenofibrate safer than a statin?

In other areas, though, fibrates actually have the edge. They are substantially better at boosting HDL levels, and only two statins, atorvastatin (Lipitor) and rosuvastatin (Crestor), can match their ability to reduce triglyceride levels. Gemfibrozil (Lopid) and fenofibrate (TriCor) appear equally safe and effective.

Article first time published on

What drugs may interact with fenofibrate?

• atorvastatin.
• colchicine.
• fluvastatin.
• idelalisib.
• ivacaftor.
• lovastatin.
• pitavastatin.
• pravastatin.

Will I lose weight taking fenofibrate?

Recently, several studies have examined the effects of PPARα agonists on energy intake, body weight, and body fat in rodent models of obesity. In selectively bred obese-prone rats, fenofibrate (100 mg/kg per day) reduced body weight gain, adiposity, food intake, and feed efficiency [2].

Does fenofibrate raise blood sugar?

Results: Fenofibrate treatment resulted in better glycemic control, as evidenced by lower fasting and postprandial blood glucose and HbAlc, decreased fasting serum insulin and leptin levels, as well as a reduction in hypertrigyceridemia and serum free fatty acids, and an increase in HDL cholesterol.

Is it better to take fenofibrate in the morning or at night?

Some people find it helps to swallow the tablet/capsule with a drink of water. You can generally take fenofibrate at a time of day to suit you, but it is best to take your doses with the same meal each day. This will help remind you to take your tablets/capsules regularly.

Can you take fenofibrate every other day?

Alternate day therapy with atorvastatin–fenofibrate combination is an effective and safe alternative to daily therapy in mixed dyslipidemia. Apart from significant cost savings, reasonable reduction in the incidence of adverse events is seen with alternate day regimen.

What causes high triglycerides?

Cause. The most common causes of high triglycerides are obesity and poorly controlled diabetes. If you are overweight and are not active, you may have high triglycerides, especially if you eat a lot of carbohydrate or sugary foods or drink a lot of alcohol.

Does fenofibrate make you tired?

Check with your doctor right away if you have dark urine, diarrhea, fever, muscle cramps or spasms, muscle pain or stiffness, or feel very tired or weak. These could be symptoms of a serious muscle problem called rhabdomyolysis, which can cause kidney problems. Pancreatitis may occur while you are using this medicine.

Is fenofibrate safe for kidneys?

No adverse effect of fenofibrate on renal function was reported. Indeed, despite an initial increase in creatinine, long-term treatment with fenofibrate reduced the rate of loss of renal function in patients with type 2 diabetes [18].

Is Lipidil a fenofibrate?

LIPIDIL contains the active ingredient fenofibrate. LIPIDIL belongs to a group of medicines known as fibric acid derivatives. LIPIDIL works through the activation of a cell nuclear receptor called PPARα, which reduces the amount of triglycerides and bad cholesterol made in the body and increases the good cholesterol.

Can you drink alcohol when taking fenofibrate?

What should I avoid while taking fenofibrate? Avoid eating foods high in fat or cholesterol, or fenofibrate will not be as effective. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

What can I take instead of fenofibrate?

• Antara (fenofibrate) Prescription only. …
• 8 alternatives.
• Niaspan (niacin) Prescription only. …
• Trilipix (fenofibric acid) Prescription only. …
• Omega 3 Acid (omega-3 acid) Prescription only. …
• Vytorin (ezetimibe / simvastatin) Prescription only. …
• Crestor (rosuvastatin) Prescription only. …
• Atorvastatin (atorvastatin)

Is fenofibrate the same as Lipitor?

Results: Atorvastatin was more efficient in the reduction of total cholesterol, whereas fenofibrate was more efficient in the reduction of triglycerides. Only atorvastatin led to a significant reduction of LDL cholesterol and apolipoprotein B. Only fenofibrate increased high-density lipoprotein cholesterol.

What is the difference between fenofibrate and gemfibrozil?

In both of these groups, fenofibrate was associated with significantly greater reductions in total cholesterol, LDL, and triglycerides than gemfibrozil (all p<0.001). In addition, fenofibrate was associated with a significantly greater increase in high-density lipoprotein cholesterol (HDL) than gemfibrozil (p<0.001).

Does fenofibrate cause coughing?

fever, chills, weakness, sore throat, mouth sores, unusual bruising or bleeding; chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or. swelling, warmth, or redness in an arm or leg.

Does fenofibrate lower LDL?

Fenofibrate lowered LDL-C by 6% and TG by 28%, and raised HDL-C by 7%. Fenofibrate slowed the angiographic progression of coronary atherosclerosis: the progression of focal coronary atheroma was 40% less in the fenofibrate group compared with placebo, without significant effect on diffuse atheroma.

Does fenofibrate cause pancreatitis?

Investigators concluded that the risk for pancreatitis is higher with fenofibrate, regardless of combination with a statin, compared to statins alone. A meta-analysis of clinical trials of statins or fibrates was conducted in order to determine whether fibrates are associated with development of pancreatitis.

Are fibrates the same as statins?

Statins lower LDL-cholesterol (LDL-C), with limited effects on other lipid parameters. Fibrates improve atherogenic dyslipidemia characterized by high triglyceride and/or low HDL-C levels and elevated concentrations of small dense LDL particles, with or without high LDL-C levels.

Does fenofibrate help with diabetes?

There is firm evidence that fenofibrate slows the progression of diabetic retinopathy and reduces the need for laser photocoagulation and vitrectomy surgery. Fenofibrate is now indicated in Australia for the reduction of diabetic retinopathy progression in patients with type 2 diabetes and existing retinopathy.

Does fenofibrate interact with metformin?

Conclusions—Fenofibrate, particularly administered together with metformin, is superior to metformin and lifestyle intervention in exhibiting beneficial effects on systemic inflammation, hemostasis, and monocyte secretory function in type 2 diabetic patients with mixed dyslipidemia.

Can statins cause belly fat?

As with many medications, statins may cause side effects, including digestive problems, muscle pain and weakness, and cognitive dysfunction. Another side effect that’s been linked to statins is weight gain.

Does fenofibrate make you poop?

Side effects: Common side effects of fenofibrate (Tricor) include stomach pain or upset, back pain, constipation, headache, dizziness, trouble sleeping, or runny or stuffy nose. Muscle damage may occur, and muscle pain, tenderness, weakness and fever should be reported promptly to your physician.